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NOMATEN ONLINE-SEMINAR December 6: New multivalent scaffolds for anions sequestration

Date
Date 2
Place
Online: https://www.gotomeet.me/NCBJmeetings/nomaten-seminar

NOMATEN ONLINE-SEMINAR

https://www.gotomeet.me/NCBJmeetings/nomaten-seminar     

Tuesday, DECEMBER 6th  2022 13:00 CET

New multivalent scaffolds for anions sequestration

Dr. Marie-Pierre Heck
Alternative Energies and Atomic Energy Commission of France (CEA), France.

Abstract:

Anions and cations are ubiquitous in nature and play very important roles in many areas, such as biological research, clinical diagnosis, industries and environmental process. There recognition and monitoring are of primordial importance in biological mechanisms, medicine and environment. The design of anion receptors is particularly challenging due to their larger size than isoelectronic cation, their strong hydration, their variety of geometries, and their sensitivity to pH. Despite numerous progress have been achieved, selective anion recognition is a real challenge, especially in water and biological media due to the intrinsic characteristics of anions.

Our research group has designed powerful receptors of anions based on bambusuril skeleton and evaluated their affinity towards halides. These neutral cavitands with a jigger-like conformation are prepared from cheap reagents using an easy and fast synthetic procedures. We have shown that such molecules exhibit highly specific recognition for iodides in organic and aqueous media making them the most efficient complexing agents currently known for which applications as sensors and imaging agents can be envisaged. Moreover, we have shown that bambusurils can be used as multivalent plateforms to link glycosidases inhibitors derived from 1-deoxynojirimycin (DNJ). These neoglycobambusurils caging-anions have inhibitory constants in the nanomolar range.

 

Bio:

Dr. Marie-Pierre Heck studied organic chemistry at the University of Strasbourg (France). She obtained her PhD degree untitled " Synthesis of amidines of therapeutic interest" in 1994 from the University of Strasbourg, under the supervision of Dr. Charles Mioskowski. She then completed a 2 years post-doctoral training with Pr. Chi-Huey Wong at Scripps Research Institute (La Jolla, California) with a Lavoisier fellowship from the french minister during which she developed glycosidase inhibitors and sialyl Lewis X mimetics.

Since 1996, she has a permanent position at the Alternative Energies and Atomic Energy Commission of France (CEA) where she is leading the chemistry group "Development of new methodologies in organic synthesis and synthesis of bioactive molecules". Her main fields of interest are organic chemistry in relation and applications to biological problems, macrocyclic chemistry, supramolecular assemblies, cage-molecules for gas encapsulation and macrocycles for anions chelation applied to labelling and imaging.



This project has received funding from the European Union Horizon 2020 research and innovation
programme under grant agreement No 857470 and from European Regional Development Fund
via Foundation for Polish Science International Research Agenda PLUS programme grant
No MAB PLUS/2018/8.
Poland
The project is co-financed from the state budget within the framework of the undertaking of the Minister of Science and Higher Education "Support for the activities of Centers of Excellence established under Horizon 2020".

Grant: 5 143 237,70 EUR
Total value: 29 971 365,00 EUR
Date of signing the funding agreement: December 2023

The purpose of the undertaking is to support entities of the higher education and science system that have received funding from the European Union budget in the competition H2020-WIDESPREAD-2018-2020/WIDESPREAD-01-2018-2019: Teaming Phase 2. in the preparation, implementation and updating of activities, maintenance of material resources necessary for carrying out activities, acquisition and modernization of scientific and research apparatus, maintenance and development of personnel potential necessary for the implementation of activities, and dissemination of the results of scientific activities.