NOMATEN SEMINAR: Nanometric Micelles for Drug Delivery and Catalysis

Date
Date 2
Place
https://www.gotomeet.me/NCBJmeetings/nomaten-seminar

Tuesday, MAY 10th 2022 13:00 (1.00PM CET)

Nanometric Micelles for Drug Delivery and Catalysis

Dr. Eric Doris, Alternative Energies and Atomic Energy Commission (CEA),
University Paris-Saclay, France.

Abstract:

Medicine has been a field where nanotechnologies have shown great promise for diagnosis and drug delivery applications. The challenge of nanomedicine consists in carrying active molecules through the different biological barriers and reaching specific targets in an efficient and non-toxic way. With the advent of nanotechnologies, different carrier systems are now available. However, the development of small biocompatible carriers with high loading capacity, extended circulation time, and favorable biodistribution has several unanswered issues.

This talk will give an overview of our findings regarding polymerized micelles obtained from original diacetylene-containing amphiphiles. Their chemical synthesis, assembly and characterization will be presented as well as some biomedical applications such as tumor imaging and drug delivery.

Micelles were also valorized by our group for synthetic applications such as the promotion of the Huisgen 1,3-dipolar cycloaddition (“click” reaction) between alkynes derivatives and azido compounds in water. Some examples illustrating the potential of the micelles in the catalysis of the “click” reaction will be presented.

 

Bio:

Dr. Eric Doris studied organic chemistry at the University of Strasbourg (France). He obtained his PhD degree in 1995 from the same University, under the guidance of Dr. Charles Mioskowski. In 1996 he completed his post-doctoral training with Sir Derek H. R. Barton (Nobel laureate) at Texas A&M University (USA). Since 1997, he has been working at the Alternative Energies and Atomic Energy Commission of France (CEA) where he is leading the Nanosciences research group. His current research interests include the synthesis of biologically active compounds, supramolecular assemblies on carbon nanotubes, and nanomedicine for drug delivery and imaging applications.

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This project has received funding from the European Union Horizon 2020 research and innovation
programme under grant agreement No 857470 and from European Regional Development Fund
via Foundation for Polish Science International Research Agenda PLUS programme grant
No MAB PLUS/2018/8.
Poland
The project is co-financed from the state budget within the framework of the undertaking of the Minister of Science and Higher Education "Support for the activities of Centers of Excellence established under Horizon 2020".

Grant: 5 143 237,70 EUR
Total value: 29 971 365,00 EUR
Date of signing the funding agreement: December 2023

The purpose of the undertaking is to support entities of the higher education and science system that have received funding from the European Union budget in the competition H2020-WIDESPREAD-2018-2020/WIDESPREAD-01-2018-2019: Teaming Phase 2. in the preparation, implementation and updating of activities, maintenance of material resources necessary for carrying out activities, acquisition and modernization of scientific and research apparatus, maintenance and development of personnel potential necessary for the implementation of activities, and dissemination of the results of scientific activities.