VTT hosted the next edition of NOMATEN Autumn School. Researchers from NCBJ in Poland and CEA in France visited Finland for the NOMATEN's internal conference in order to share the latest research outcomes and share the expertise. The School has been followed by a series of site visits at VTT and Aalto University.

NOMATEN School is a format of internal collaboration facilitated by an on-site event for NOMATEN consortium partners (NCBJ, CEA, VTT). Moreover, it allows the team members to exchange not only the research outcomes, but also the ideas concerning other developments within the NOMATEN project. The agenda contained the topics on materials informatics and modeling, materials characterization, functional properties of materials as well as radiopharmaceuticals.

On Thursday September 28 the participants attended a series of site visits at research infrastructures owned by VTT and Aalto University:

• VTT Centre for Nuclear Safety (CNS)
• VTT Research Hall
• VTT Protein production lab
• Aalto University Nanomicroscopy Centre

In addition, a presentation about irradiation opportunities at MARIA Research Reactor in National Centre for Nuclear Research has been given by Łukasz Murawski from the reactor's team.

FINAL AGENDA

TEAMS links to the meetings included: Day 1, Day 2 and MARIA Reactor presentation

DAY 1 - Tuesday 27.9.2022

8:30 Registration, Innopoli 2, address Tekniikantie 14, Espoo

TEAMS link: Click here to join the meeting ; Meeting ID: 331 784 093 374

Passcode: xRpYYn Download Teams | Join on the web

Meeting room Edison 1-2

Day 1 - Session 1 INTRODUCTIONS - Chair Maria Oksa, VTT

8:55 – 9:00      Welcome - opening of the school, Maria Oksa

9:00 – 9:10      NOMATEN - the EU "teaming project" and the framework of the school, Jacek Jagielski

9:10 – 9:30      The CoE NOMATEN - presentation of the centre, and objectives and scientific content of the school, Mikko Alava

9:30 – 9:40      Brief introduction to NCBJ, hosting the CoE NOMATEN, Pawel Sobkowicz

9:40 – 9:50      Brief introduction to CEA, partner of the CoE NOMATEN, Gilles Moutiers and Frédéric Dollé

9:50 – 10:00    General introduction of VTT, partner of the CoE NOMATEN, and hosting the organisation of the school, Tommi Nyman

10:00 – 10:40 Coffee break

10:40 – 10:50 RG @CoE NOMATEN: Functional properties, Łukasz Kurpaska

10:50 – 11:00 RG @CoE NOMATEN: Complexity in functional material, Mikko Alava

11:00 – 11:10 RG @CoE NOMATEN: Materials structure, informatics and functions, Stefanos Papanikoloau

11:10 – 11:20 RG @CoE NOMATEN: Materials characterization, Iwona Jóźwik

11:20 – 11:30 RG @CoE NOMATEN: Radiopharmaceuticals, Marek Pruszyński

11:30 – 12:30 Round table and discussion

12:30 – 13:30 Lunch break and discussions

Day 1 - Session 2 MATERIALS SCIENCE (nuclear) - Chair Gilles Moutiers, CEA

13:30 – 14:15 The SOLEIL facility and new developments of the MARS beam line, Jean-Luc Béchade, CEA

14:15 – 14:45 XRD analyses on highly irradiated structural materials (HR XRD, XAS), Raphaelle Guillou, CEA

14:45 – 15:15 Characterization of a UO2 spent nuclear fuel by HR-XRD and HERFD-XANES on MARS beamline, Vincent Klosek, CEA

15:15 – 15:45 Study of  SIMFUEL  compounds  in  relationship with thermodynamical approaches (XRD and XAS), Christine Guéneau, CEA

15:45 – 16:00 Coffee break

16:00 – 16:30 Mechanical properties of irradiated structural materials, Janne Heikinheimo, VTT

16:30 – 17:00 Radiation damage resistance and mechanical properties of ODS-CSAs submitted to high-temperature irradiation, Sri Tapaswi Nori, NOMATEN

17:00 – 17:30 Understanding radiation damage mechanism and functional properties in high-

/medium- entropy alloys, Wenyi Huo, NOMATEN

17:30 – 18:00 PhD session, chair Christophe Gallé, CEA

Artur Olejarz: Effect of milling time on the microstructure and mechanical properties of High-Entropy Alloys sintered by Spark Plasma Sintering technique (NOMATEN)

Magdalena Wilczopolska: Raman spectroscopy as a characterization tool for various types of graphite modified by the ion beam for nuclear applications (NOMATEN)

Kinga Suchorab: Studying corrosion mechanism in zirconium and its alloys, impact of radiation damage on the formation of zirconia polymorphs at high temperature (NOMATEN)

Agata Zaborowska: Impact of radiation damage on mechanical and structural properties of amorphous alumina coatings (NOMATEN)

Katarzyna Mulewska: Investigation of the plasticity effect and radiation damage resistance via nanoindentation in Fe-Cr alloys (NOMATEN)

Martin Madelain: study of the behaviour under irradiation of Ni-based alloys from additive manufacturing for Molten Salt Reactors (CEA)

18:00 – 18:30 Exchange time: Parallel scientific round tables and informal discussions on dedicated topics, Łukasz Kurpaska, NOMATEN, and Jean-Luc Béchade, CEA

19:15 Welcome dinner at restaurant Fat Lizard, address Tietotie 1

DAY 2 - Wednesday 28.9.2022

Day 2 - Session 3 MATERIALS SCIENCE (non-nuclear) - Chair Mikko Alava, NOMATEN

TEAMS link: Click here to join the meeting ; Meeting ID: 399 396 305 058

Passcode: aqcYLi Download Teams | Join on the web

8:30 – 08:55    Coffee

8:55 – 9:00      Welcome – Mikko Alava, NOMATEN

9:00 – 9:30      Iwona Jozwik: FIB-SEM application to materials studies at NOMATEN CoE

9:30 – 10:00 Kamran Karimi: Machine learning, micro-structural descriptors, and their predictive capacity of material properties: case studies of a metallic glass and a complex concentrated alloy

10:00 – 10:30 Fabrizio Rovaris: Discrete Dislocation Dynamics and Multiscale Modeling of nano- and micro-scale testing of Materials

10:30 – 10:45 Coffee break

10:45 – 11:00 PhD student introductions (5 x 3 mins)

11:00 – 11:30 Stefanos Papanikolaou: ML advances at NOMATEN

11:30 – 12:00 Silvia Bonfanti: Complex metal glasses

12:00 – 13:30 Lunch break and discussions

Day 2 - Session 4 RADIOPHARMACEUTICALS SCIENCES - Chair Frédéric Dollé, CEA

13:30 – 13:55 VTT´s recombinant antibody technology: current and future applications, Kristiina Iljin, VTT

13:55 – 14:20 Radiolabeling of biomolecules via disulfide rebridging, Mylène Richard, CEA

14:20 – 14:35 PSMA ligands for radiolabeling: from bench to clinic, Urszula Karczmarczyk,POLATOM

14:35 – 14:50 Challenges in radioiodination of biomolecules, Anna Krzyczmonik, NCBJ

14:50 – 15:05 Microfluidic synthesizer iMiDEV^TM in the production of ¹⁸F-radiotracers, Salla Lahdenpohja, CEA

15:05 – 15:20 Coffee break

15:20 – 15:45 Clinical trials in radiopharmacy - POLATOM's experience, Renata Mikolajczak, POLATOM (online)

15:45 – 16:10 Challenges and opportunities for utilising metal-organic frameworks (MOFs) in biological applications, Mikko Vepsäläinen, VTT

16:10 – 16:35 Fluorinated micelles encapsulating Au nanoparticles for radiotherapy, Edmond Gravel, CEA

16:35 – 17:00 Targeting the immune system with innovative immunoPET ligands: new insights to potentialize immunotherapy impact, Charles Truillet, CEA

17:00 – 17:15 Nucleolipids and their application in medicine, Swastika Tiwari, NCBJ (online)

17:15 – 17:30 Coffee break

17:30 – 18:00 PhD session

Jolanta Zaborniak: Development and validation of scoring functions for modelling interactions with targets relevant to radiopharmacy (POLATOM, online)

Mateusz Pociegiel: Radiosynthesis of novel 131I-labelled 1,2,3-dithiazole-based radiopharmaceuticals for LAT-1 molecular imaging and therapy (POLATOM, online)

Eugénie Pincemail: Synthesis, radiolabeling and in vitro and in vivo characterization of novel P2Y12 purinergic receptor radiotracers (CEA)

Sébastien Beuché: Synthesis of novel radiotracers for PET imaging of cellular dysregulation in oncology (CEA)

Ihab Shokair: Organic boron-derivative precursors for radiohalogenation of biomolecules (NCBJ)

18:00 Autumn school networking and innovation

Innopoli 2 lobby with some snacks

19:30 End of Day 2

Free time for own dinner plans and visit to Helsinki etc.

DAY 3 - Thursday 29.9.2022

Visits to labs – meeting in the Centre for Nuclear Safety (CNS), address Kivimiehentie 3, Espoo

• Remember to bring your passports / ID cards with you!
• They will be checked on Thursday 29.9. at CNS before the visits

8:30 – 9:00 Welcome and entrance formalities = passport/ID checks, VTT, Kivimiehentie 3

9:00 – 12:00 Visits

#1 VTT Centre for Nuclear Safety (CNS) (link), Kivimiehentie 3 #2 VTT Research Hall, Kemistintie 3

#3 VTT Protein production lab, Tietotie 2

#4 Aalto University Nanomicroscopy Centre (link), Puumiehenkuja 2

Visitors have been shared to the groups (list as appendix). Maximum two facilities per person.

Schedule for visits:

9:15 – 10:15 First visit place – groups 1, 2, 3 and 4

Change at CNS 10:30

10:45 – 11: 45 Second visit place – groups 5, 6, 7 and 8

12:00 – 13:00 Lunch, VTT CNS building, Kivimiehentie 3, Espoo

13:00 – 14:00 MARIA Reactor presentation by Łukasz Murawski, Kierownik Działu Technologii Napromieniania (DTN), meeting room Einstein, CNS building, VTT, address Kivimiehentie 3, Espoo

TEAMS link: Click here to join the meeting ; Meeting ID: 343 904 381 382

Passcode: HoSScD Download Teams | Join on the web

14:00 End of the school

Groups for lab visits 29.9.2022, 9:15 – 10:15 First visit / Groups 1-4

VTT Centre for Nuclear Safety (CNS)
Group 1

VTT Research hall
Group 2

VTT Protein Production lab
Group 3

Aalto University nanomicroscopy centre
Group 4

Groups for lab visits 29.9.2022, 10:45 – 11: 45 Second visit / Groups 5-8

VTT Centre for Nuclear Safety (CNS)
Group 5

VTT Research hall
Group 6

VTT Protein Production lab
Group 7

Aalto University nanomicroscopy centre
Group 8